Guidelines for diagnosis and treatment (UK) – An Update

For the first time in ten years, the Guidelines for the Diagnosis and Treatment of Cholangiocarcinoma in the UK have been updated by a group of GI specialists*.

These are evidence based Guidelines, and were originally published in 2002. In this, the first update since that time, the specialists have based their work on a comprehensive review of the most recent literature, and have also used data from randomised controlled trials, systematic reviews, meta-analyses, cohort, prospective and retrospective studies.

The Guidelines were submitted to the British Society of Gastroenterology (BSG) mid 2011, and circulated for peer review nationally. Also, because the BSG wanted to have patient input, in September 2011 AMMF was asked to review the Guidelines from a layman/patient’s perspective, which we duly did. AMMF’s contribution is acknowledged in the introductory paragraph, ‘ … This manuscript has been developed with the support of The British Liver Trust and the UK cholangiocarcinoma charity, the Alan Morement Memorial Fund.’

Following approval by the British Society of Gastroenterology, the document was submitted for publication to the journal Gut. Gut then put it out to international reviewers, who came back with many pages of comments which had to be answered point by point. The final document has now been published by Gut and we are at last able to make it available on AMMF’s website.

The intention is that these Guidelines will be circulated to all specialist doctors and nurses in the field: hepatobiliary medicine/endoscopy/surgery, hepatology/GI physicians and surgeons, and GI cancer specialists.

This is a thorough, comprehensive overview of the situation regarding the diagnosis and treatment of cholangiocarcinoma in the UK today. To read it in full, click here

*The group: Shahid A. Khan, Brian R. Davidson, Robert Goldin, Nigel Heaton, John Karani, Stephen P. Pereira, William M. C. Rosenberg, Simon D. Taylor-Robinson, Paul Tait, Andrew V. Thillainayagam, Howard C. Thomas, Harpreet Wasan

Hepatology and Gastroenterology Section (S.A. Khan, S.D Taylor-Robinson, A. Thillainayagam, H.C. Thomas), Department of Medicine and Department of Histopathology (R. Goldin), Imperial College London, St Mary’s Hospital Campus, South Wharf Road, London W2 1NY, United Kingdom; Department of Oncology (H. Wasan), Imperial College London Hammersmith Hospital Campus, Du Cane Road, London W12 OHS; Department of Hepatobiliary Surgery (B.R. Davidson) and University College London Centre for Hepatology (S.P. Pereira, W.M.C. Rosenberg), Division of Medicine, University College London, Royal Free and University College Medical School, Pond Street, London, London, NW3 2QG; Department of Hepatobiliary and Pancreatic Surgery (N. Heaton, P. Karani), King’s College Hospital, Denmark Hill, London, SE5 9RS.

Update April 2014

International guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

International guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma

International Guidelines for ICC
An international panel of CC specialists from five countries, including Dr Shahid Khan and Dr John Bridgewater from the UK, have collaborated on international “Guidelines for the diagnosis and management of intrahepatic cholangiocarcinoma”, and these guidelines have now been published.   

The coordinating centre, on behalf of ILCA was the US Mayo Clinic ( , and the panel of experts was:

Chair: Professor Gregory Gores (USA), Dr John Bridgewater (UK), Dr Shahid Khan (UK), Dr Tushar Patel (US), Professor Tim Pawlik (US), Professor Joong-Won Park (Korea), Professor Josep M Llovet (Spain), Dr Peter Galle (Germany)

To read the guidelines in full, click here

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April 2014


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